안녕하세요.
서울토토사이트 펫교 뇌영상센터(SNUBIC)에 새로 도입된 고경사 확산 자기공명 영상(High-Gradient diffusion MRI, HG-dMRI) 시스템과 최신 뇌영상(Advanced neuroimaging) 기술을 소개하는 ART FAIR SERIES 세번째 세션을 안내드립니다.
글림프계(glymphatic system)은 뇌 대사 노폐물 제거를 담당하는 중요한 체계로, 그 기능 저하는 신경퇴행성 질환 발병과 뇌 항상성에 직결됩니다. 이번 세션에서는 DTI, 동적 조영증강 MRI, 척수강 조영 MRI와 첨단 영상처리 및 모델링 알고리즘을 통해 글림프계 기능을 정량화 하는 최신 방법을 다룹니다. 서울토토사이트 펫교 뇌영상센터의 핵심 연구자인 최승홍 교수님께서는 이 분야의 선도 연구자로서, Cima.X의 고해상도 확산영상을 이용한 글림프계 연구 분야의 난제 접근 방법을 소개하실 예정입니다.
* 참석을 원하시면 다음 링크 또는 QR코드로 사전 신청 폼을 제출해야 합니다 (사전접수 기간: ~8.18 월요일 정오, 선착순)
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일시: 2025년 8월 21일(목) 오전 11:00
장소: 서울토토사이트 펫교 28동 303호
사전신청 방법: 구글폼 제출, 선착순, 마감: 8.18(월) 12:00 정오 KST
혜택: 사전 신청자에 한해 현장에서 점심 도시락을 제공합니다.
연사: 최승홍 교수 (센터 핵심 연구자, 의과토토사이트 펫 영상의학과)
제목: Visualizing Glymphatic Pathways: Innovative MRI Approaches for Flow Analysis
초록: The glymphatic system has emerged as a critical facilitator of metabolic waste clearance in the central nervous system, with implications for neurodegenerative disease pathogenesis and brain homeostasis. Traditional methods for studying glymphatic function have relied on invasive procedures or exogenous tracers, limiting their utility for translational and clinical applications. Recent advances in magnetic resonance imaging (MRI) have enabled non-invasive assessment of glymphatic transport and provided unprecedented insights into the spatial and temporal dynamics of cerebrospinal fluid (CSF) and interstitial fluid (ISF) flow.
In this talk, I present innovative MRI methodologies to visualize and analyze glymphatic pathways in vivo, focusing on techniques such as diffusion tensor imaging (DTI), intrathecal contrast-enhanced MRI, and dynamic contrast-enhanced MRI. These approaches allow for quantitative and qualitative evaluation of glymphatic function, including tracer movement, perivascular transport, and regional differences in CSF-ISF exchange.
Utilizing advanced image processing and modeling algorithms, we were able to delineate the perivascular spaces and measure fluid propagation through brain parenchyma with high spatial resolution. Our findings demonstrate that glymphatic flow patterns are markedly influenced by physiological states such as sleep, anesthesia, and exercise. Moreover, alterations in glymphatic transport were observed in models of aging and neurodegenerative conditions, highlighting the clinical relevance of MRI-based glymphatic visualization.
The incorporation of dynamic imaging protocols enabled us to capture the real-time kinetics of solute clearance and revealed regional heterogeneity in glymphatic function across cortical and subcortical structures. Notably, these novel MRI techniques correlate with traditional histological and tracer-based measurements, validating their utility for preclinical and potential clinical investigation.
In conclusion, our study underscores the significance of innovative MRI approaches for elucidating glymphatic system physiology and pathophysiology. The ability to non-invasively visualize and quantify glymphatic pathways represents a major advancement in neuroimaging, with substantial implications for early diagnosis and monitoring of brain disorders associated with impaired waste clearance. These methods have the potential to accelerate translational research and guide therapeutic strategies targeting glymphatic dysfunction.
42메뉴열기snubic@snu.ac.kr